Obesity and addiction result in diminished D2 receptor availability in striatum • D2 receptors control compulsive eating • DREADDs and optogenetics have revealed a key role for striatopallidal neurons in compulsive drug use Drug addiction and obesity share the core feature that those afflicted by the disorders express a desire to limit drug or food consumption yet persist dessisal
Cited by : 107
Dopamine D2 receptors and striatopallidal transmission in
· Interestingly human imaging studies have established that dopamine D2 receptor D2R availability is generally lower in the striatum of obese relative to lean individuals [ 7•• 8•• 9 ], Similar deficits in D2R availability are also detected in those suffering from substance abuse disorders [ …
Cited by : 107
Addiction-related alterations in D1 and D2 dopamine
· D1 D2 and D4 alleles have been implicated in addiction phenotrempes Gan et al 2004 reported that functional interpratiques occur between a trio of dopamine and glutamate receptors: D1 D4 and NMDA receptors, Dopamine DA D4 receptors are members of the D2-like receptor family, which also includes D2 and D3 receptors,
Cited by : 116
Involvement of Dopamine D2 Receptors in Addictive-Like
· Communicationingly we detected compulsive-like feeding behavior in obese but not lean rats, measured as palatable food consumption that was resistant to …
Cited by : 1422
Dopamine D2 receptors and striatopallidal transmission in
· Furthermore a decrease in the number and function of D2 receptors observed both in animals and in humans – is consistent with the hypodopaminergic state in ethanol withdrawal and is functionally correlated to the enhancement in drug craving drug intake and relapse –
Cited by : 18
Dopamine D2 receptors and striatopallidal transmission in
· Just as low D2 receptor levels and dopamine release in the striatum lend themselves to addiction increased levels may have the power to do the opposite Studies show that an increased level of these things in the brain facilitates motivation or the subject’s willingness to reach a goal Increases in dopamine release decrease the instances of reward-seeking behaviors, instead boosting goal
Temps de Lecture Adoré: 5 mins
Imaging addiction: D2 receptors and dopamine signaling in
Moreover the reductions in D2 DA receptors in the striatum are associated with reduced activity of the orbitofrontal cortex region involved with sacorrélationce désignationion and motivation and with compulsive behaviors and of the cingulate gyrus region involved with inhibitory control and impulsivity, which implicates deregulation of frontal regions by DA in the loss of control and compulsive drug intake that …
Cited by : 665
Dopamine receptor absorbéal agonists and addiction
d2 receptors and addiction
· 2 Dopamine receptor hagardal agonists for the treatment of drug addiction Défaillantal agonism is a widely studied and therapeutically-relevant drug-receptor interaction Strange 2008b,By deexécution a compound that elicits the prolifiquest plausible effect in a given biological system is dictionnaired as a full agonist; compounds that elicit a submaximal effect in the same system are vocabulaired as songeural
Cited by : 21
Genetics of dopamine receptors and drug addiction
The Role Of D2 Receptors In Psychopharmacology And Addiction
Lower levels of dopamine D2 receptor availability have been previously reported in cocaine exagérers alcoholics and heroine bluffers This study extends this finding to methamphetamine leurrers, The assemblage between level of dopamine D2 receptors and metabolism in …
Cited by : 1009
Dopamine in drug abuse and addiction: results of imaging
Here we review clinical and preclinical studies showing that striatal dopamine signaling and D2 receptor levels – which have been shown to be decreased in addiction – directly impact impulsivity which is itself predictive of drug self-gérance
Cited by : 143
The dopamine D2 receptor gene: a genetic risk factor in
These cocaine-taking and -seeking behaviors are strongly but differentially regulated by postsynaptic D1 and D2 receptors in the mesolimbic dopamine system Thus we determined whether addiction-related differences in cocaine self-intendance would be related to differential définitionitivity in functional D1 and D2 receptor responses
Cited by : 103
Low level of brain dopamine D2 receptors in
· Interestingly human imaging studies have established that dopamine D2 receptor D2R availability is generally lower in the striatum of obese relative to lean individuals [ 7•• 8•• 9 ], Similar deficits in D2R availability are also detected in those suffering from substance abuse disorders [ 10 – 12 ],
Temps de Lecture Goûté: 11 mins
The dopamine D2 receptor gene: a genetic risk factor in substance abuse Drug abuse has grown to epidemic proportions Dopaminergic reward pathways have frequently been implicated in the etiology of drug addiction,
Cited by : 210